Linking cortical and connectional pathology in schizophrenia

MA Di Biase; VL Cropley; L Cocchi; A Fornito; F Calamante; EP Ganella; C Pantelis; A Zalesky

Conference Proceedings

Linking cortical and connectional pathology in schizophrenia

MA Di Biase, VL Cropley, L Cocchi, A Fornito, F Calamante, EP Ganella, C Pantelis, A Zalesky

Schizophrenia Bulletin | OXFORD UNIV PRESS | Published : 2019

DOI: 10.1093/schbul/sby121

Abstract

Schizophrenia is associated with cortical thickness (CT) deficits and breakdown in white matter microstructure. Whether these pathological processes are related remains unclear. We used multimodal neuroimaging to investigate the relationship between regional cortical thinning and breakdown in adjacent infracortical white matter as a function of age and illness duration. Structural magnetic resonance and diffusion images were acquired in 218 schizophrenia patients and 167 age-matched healthy controls to map CT and fractional anisotropy in regionally adjacent infracortical white matter at various cortical depths. We found a robust and reproducible relationship between thickness and anisotropy ..

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University of Melbourne Researchers

Maria Di Biase Author

Vanessa Cropley Author

Christos Pantelis Author

Andrew Zalesky Author

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Grants

Awarded by Sylvia and Charles Viertel Charitable Foundation

Funding Acknowledgements

This research was supported by Melbourne Bioinformatics at the University of Melbourne, grant number UOM0014. Data for this study were provided by the Australian Schizophrenia Research Bank (ASRB), which is supported by the National Health and Medical Research Council of Australia (enabling grant 386500), the Pratt Foundation, Ramsay Health Care, the Viertel Charitable Foundation, and the Schizophrenia Research Institute. M.A.D. was supported by an Australian Rotary Health, Ian Scott PhD Scholarship in Mental Health. V.L.C. was supported by a National Health and Medical Research Council (NHMRC) Early Career Fellowship (628880), a Brain and Behavior Research Foundation (NARSAD) Young Investigator Award (21660), and a University of Melbourne Faculty of Medicine, Dentistry, and Health Sciences Research Fellowship. L.C. was supported by two NHMRC grants (APP1099082, APP1138711). A.F. was supported by an Australian Research Council Future Fellowship (FT130100589) and the Charles and Sylvia Viertel Foundation. F.C. was supported by an NHMRC Senior Research Fellowship. C.P. was supported by an NHMRC Senior Principal Research Fellowship (628386 and 1105825). A.Z. was supported by an NHMRC Research Fellowship (1047648). None of the funding sources played any role in the study design; in the collection, analysis, or interpretation of data; in the writing of the manuscript; or in the decision to submit the manuscript for publication.